The aim of our study is to investigate the dose-dependent biological system effect of hexagonal boron nitride (hBN) nanoparticles, which is directly produced nanoscale, in vivo. Wistar albino rats (n = 80) weighing 200–250 g were divided into eight groups (n = 10). The acute effects of hBN NPs (i.v) on the rats were investigated by measuring the biochemical, hematological parameters and oxidant-antioxidant status. The results show that no significant change was observed in the hematological and biochemical parameters when the control group and other low dose groups were compared, except for the 1600 and 3200 µg/kg b.w. dose groups. Histological detection indicated that 1600 and 3200 µg/kg hBN NPs treatment could induce significant damage in the liver, kidney, heart, spleen and pancreas. With the findings obtained, it can be seen that hBN NPs cannot be evaluated independently of particle morphology, and that the hBN NPs used in this study may be suitable for biomedical applications where low doses between 50 and 800 µg/kg are not toxic.

我们研究的目的是研究六价氮化硼（hBN）纳米粒子的剂量依赖性生物系统效应，该纳米粒子直接在体内产生。体重200–250 g的Wistar白化病大鼠（n = 80）分为八组（n = 10）。通过测量生化，血液学参数和氧化剂-抗氧化剂状态，研究了hBN NPs（iv）对大鼠的急性作用。结果表明，与对照组和其他低剂量组相比，除1600和3200 µg / kg bw剂量组外，血液学和生化指标没有明显变化。组织学检测表明，分别以1600和3200 µg / kg的hBN NPs处理可引起肝，肾，心脏，脾脏和胰腺的明显损害。有了发现，