Previous studies have examined the associations of meteorological factors with blood pressure; however, these associations have not fully elucidated, especially lacking of evidence from cohort study, little information about the associations of cold pressor sensitivity with blood pressure and its fluctuation. The objective of this study was to investigate the outdoor and indoor temperature, barometric pressure, humidity, and cold pressor sensitivity with blood pressure and its fluctuation. Forty-eight healthy subjects were recruited, and response of blood pressure to cold exposure was measured with cold pressor test (CPT). Then, all the subjects were followed up, and blood pressure was measured every half a month in a period of consecutive 12 months. Multiple panel analysis with random-effects generalized least squares (GLS) regression was used to analyze the effect of the outdoor and indoor temperature, barometric pressure, humidity, and response to cold pressor exposure on blood pressure. Outdoor and indoor temperature and humidity were found to be independently associated with blood pressure (all the P values < 0.05). The response to cold exposure positively associated with blood pressure and its fluctuation ( P < 0.05). The subjects with higher cold pressor sensitivity had about 4.7 mmHg higher maximum difference of SBP in 1 year than the subjects with lower sensitivity. Outdoor and indoor temperature, humidity, and response to cold exposure are associated with blood pressure and its fluctuation. These findings provided extending evidence on blood pressure management in clinic and preventive practice.

中文翻译：

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冷升压的个体敏感性、与血压相关的环境气象因素及其波动

以前的研究检查了气象因素与血压的关系；然而，这些关联尚未完全阐明，尤其是缺乏来自队列研究的证据，关于冷升压敏感性与血压及其波动之间关联的信息很少。本研究的目的是调查室外和室内温度、气压、湿度和冷升压敏感性与血压及其波动的关系。招募了 48 名健康受试者，通过冷加压试验 (CPT) 测量血压对冷暴露的反应。然后对所有受试者进行随访，连续12个月每半个月测量一次血压。使用随机效应广义最小二乘 (GLS) 回归的多面板分析来分析室外和室内温度、气压、湿度和对冷加压剂暴露的反应对血压的影响。发现室外和室内温度和湿度与血压独立相关（所有 P 值 < 0.05）。对冷暴露的反应与血压及其波动呈正相关（ P < 0.05）。冷升压敏感性较高的受试者在 1 年内的 SBP 最大差异比敏感性较低的受试者高约 4.7 mmHg。室外和室内的温度、湿度和对寒冷暴露的反应与血压及其波动有关。