Tumor metastasis comprises a series of coordinated events that culminate in dissemination of cancer cells to distant sites within the body representing the greatest challenge impeding effective therapy of cancer and the leading cause of cancer-associated morbidity. Cancer cells exploit multiple genes and pathways to colonize to distant organs. These pathways are integrated and regulated at different levels by cellular- and extracellular-associated factors. Defining the genes and pathways that govern metastasis can provide new targets for therapeutic intervention. Melanoma differentiation associated gene-9 ( mda-9 ) (also known as Syntenin-1 and SDCBP (Syndecan binding protein)) was identified by subtraction hybridization as a novel gene displaying differential temporal expression during differentiation of melanoma. MDA-9/Syntenin is an established Syndecan binding protein that functions as an adaptor protein. Expression of MDA-9/Syntenin is elevated at an RNA and protein level in a wide-range of cancers including melanoma, glioblastoma, neuroblastoma, and prostate, breast and liver cancer. Expression is increased significantly in metastatic cancer cells as compared with non-metastatic cancer cells or normal cells, which make it an attractive target in treating cancer metastasis. In this review, we focus on the role and regulation of mda-9 in cancer progression and metastasis.

中文翻译：

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MDA-9/Syntenin/SDCBP：对独特多功能支架蛋白的新见解

肿瘤转移包括一系列协调事件，最终导致癌细胞扩散到体内远处部位，这是阻碍有效治疗癌症的最大挑战，也是癌症相关发病率的主要原因。癌细胞利用多种基因和途径来定殖到远处器官。这些途径被细胞和细胞外相关因子在不同水平上整合和调节。定义控制转移的基因和途径可以为治疗干预提供新的靶点。黑色素瘤分化相关基因 9 (mda-9)（也称为 Syntenin-1 和 SDCBP（Syndecan 结合蛋白））通过减法杂交鉴定为在黑色素瘤分化过程中表现出差异时间表达的新基因。MDA-9/Syntenin 是一种成熟的 Syndecan 结合蛋白，可作为衔接蛋白发挥作用。在包括黑色素瘤、胶质母细胞瘤、神经母细胞瘤以及前列腺癌、乳腺癌和肝癌在内的多种癌症中，MDA-9/Syntenin 的表达在 RNA 和蛋白质水平上都升高了。与非转移性癌细胞或正常细胞相比，转移性癌细胞中的表达显着增加，这使其成为治疗癌症转移的有吸引力的靶标。在这篇综述中，我们重点关注 mda-9 在癌症进展和转移中的作用和调控。与非转移性癌细胞或正常细胞相比，转移性癌细胞中的表达显着增加，这使其成为治疗癌症转移的有吸引力的靶标。在这篇综述中，我们重点关注 mda-9 在癌症进展和转移中的作用和调控。与非转移性癌细胞或正常细胞相比，转移性癌细胞中的表达显着增加，这使其成为治疗癌症转移的有吸引力的靶标。在这篇综述中，我们重点关注 mda-9 在癌症进展和转移中的作用和调控。