Evolutionary and recombination analysis of porcine reproductive and respiratory syndrome isolates in China.,Virus Genes

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Evolutionary and recombination analysis of porcine reproductive and respiratory syndrome isolates in China.
Virus Genes ( IF 1.9 ) Pub Date : 2020-03-20 , DOI: 10.1007/s11262-020-01751-7
Zhendong Zhang ₁ , Xiangyang Qu ₂ , Hongliang Zhang ₃ , Xudong Tang ₁ , Ting Bian ₁ , Yingjun Sun ₂ , Mingming Zhou ₂ , Fubo Ren ₂ , Ping Wu ₁

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Seven strains of porcine reproductive and respiratory syndrome virus (PRRSV) were isolated from 2014 to 2017 in the Shandong province of China and their genomes were sequenced and analyzed. Results showed that all seven of the isolates belong to PRRSV 2, and are clustered into four lineages (lineage 1, 3, 5 and 8) based on comparisons of the ORF5 gene. Comparative analysis of genomes and specific amino acid sites revealed that three of the strains (SDwh1402, SDwh1602 and SDwh1701) have evolved directly from modified live virus (MLV) JXA1-P80, TJM-F92 and IngelvacPRRS. Further recombination analysis revealed that two of the strains (SDyt1401 and SDwh1601) were the result of a recombination event between MLVs JXA1-P80 and NADC30 while two other strains (SDwh1403 and SDqd1501) were the result of recombination between MLVs IngelvacPRRS and NADC30 and HP-PRRSV and QYYZ, respectively. Our results add to the data on MLV evolution and PRRSV recombination and provide a better understanding of the epidemiology of PRRSV in China.

更新日期：2020-03-20

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