Abstract

This paper considers current views on the classical determinants of Helicobacter pylori virulence, pathogenetic effects of phosphorylation, and the process of CagA translocation into gastric mucosa (GM) cells and characterizes surface membrane receptors of VacA binding to epithelial cells of the gastric mucosa. The necessity of genetic typing of Helicobacter pylori to determine the potential virulence of a microorganism in order to predict the course of H. pylori-associated diseases and to select targeted therapy is substantiated.

中文翻译：

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幽门螺杆菌与胃粘膜细胞相互作用的分子和遗传方面。

摘要

本文考虑了有关幽门螺杆菌毒力的经典决定因素，磷酸化的致病作用以及CagA转运到胃粘膜（GM）细胞过程的最新观点，并描述了VacA与胃粘膜上皮细胞结合的表面膜受体。证实了幽门螺杆菌的基因分型以确定微生物的潜在毒力以预测幽门螺杆菌相关疾病的进程并选择靶向治疗的必要性。