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Molecular and Genetic Aspects of Helicobacter pylori Interaction with Cells of Gastric Mucosa

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Abstract

This paper considers current views on the classical determinants of Helicobacter pylori virulence, pathogenetic effects of phosphorylation, and the process of CagA translocation into gastric mucosa (GM) cells and characterizes surface membrane receptors of VacA binding to epithelial cells of the gastric mucosa. The necessity of genetic typing of Helicobacter pylori to determine the potential virulence of a microorganism in order to predict the course of H. pylori-associated diseases and to select targeted therapy is substantiated.

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Authors and Affiliations

  1. Vinnytsia National Pyrohov Memorial Medical University, 21018, Vinnytsia, Ukraine

    D. S. Sukhan, S. V. Vernygorodskyi, N. V. Haidukov & H. P. Ludkevich

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  1. D. S. Sukhan
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  2. S. V. Vernygorodskyi
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  3. N. V. Haidukov
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Correspondence to D. S. Sukhan, S. V. Vernygorodskyi, N. V. Haidukov or H. P. Ludkevich.

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The authors declare that they have no conflict of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.

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Translated by K. Lazarev

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Sukhan, D.S., Vernygorodskyi, S.V., Haidukov, N.V. et al. Molecular and Genetic Aspects of Helicobacter pylori Interaction with Cells of Gastric Mucosa. Cytol. Genet. 54, 147–153 (2020). https://doi.org/10.3103/S0095452720020139

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