Regenerative endodontics is a biologically based treatment designed for immature permanent teeth with necrotic pulp to replace dentin and root structures, as well as dental pulp cells. This procedure has become a part of novel modality in endodontics therapeutic manner, and it is considered as an alternative to apexification. In the last decade, numerous case reports, which describe this procedure, have been published. This therapeutic approach succeeded due to its lower financial cost and ease of performance. Although the clinical protocol of this procedure is not standardized and the effects of irrigants and medicaments on dental stem cells fate remain somewhat ambiguous, however when successful, it is an improvement of endodontics treatment protocols which leads to continued root development, increased dentinal wall thickness, and apical closure of immature teeth. To ensure a successful regenerative procedure, it is essential to investigate the appropriate disinfection protocols and the use of biocompatible molecules in order to control the release of growth factors and the differentiation of stem cells. This is the first review in the literature to summarize the present knowledge regarding the effect of intracanal irrigants and medicaments on the dental derived stem cells fate in regenerative endodontic procedures.

中文翻译：

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再生根管治疗中腔内冲洗液和药物对牙科衍生干细胞命运的影响：更新。

再生牙髓治疗是一种基于生物学的治疗方法，旨在用坏死牙髓替代牙本质和牙根结构以及牙髓细胞，用于不成熟的恒牙。该方法已经成为牙髓治疗新方式的一部分，被认为是根尖化治疗的替代方法。在过去的十年中，已经发布了许多描述此过程的案例报告。这种治疗方法因其较低的财务成本和易于操作而获得成功。尽管该程序的临床方案尚未标准化，并且冲洗液和药物对牙齿干细胞命运的影响仍然有些模棱两可，但是，如果成功，这是牙髓治疗方案的一种改进，可导致牙根持续发育，牙本质壁厚度增加，以及未成熟牙的根尖闭合。为确保成功的再生程序，必须研究适当的消毒方案并使用生物相容性分子来控制生长因子的释放和干细胞的分化。这是文献中的第一篇综述，总结了有关在再生牙髓手术中使用管内冲洗剂和药物对牙科干细胞命运的影响的现有知识。