Abstract

In the current study, we introduce “click chemistry” as a powerful tool to tailor cyclodextrin–cellulose combination product followed by the inclusion of ciprofloxacin hydrochloride (CipHCl) as antibacterial agent. Initially, beta-cyclodextrin (β-CD) and cellulose fibers (CFs) were modified so as to be mono-6-propargylamino-6-deoxy-β-CD (Pro-β-CD) and azidated cellulose fibers (CFs-N₃), respectively. Afterward, the “click reaction” was carried out between Pro-β-CD and CFs-N₃ to fabricate a covalent grafting of β-CD onto CFs resulting in click product (CFs-N₃@Pro-β-CD). The drug-delivery kinetics of the loaded CipHCl was performed by immersing samples into an aqueous solution, and the amount of adsorbed and released CipHCl was measured, as a function of time, by UV spectroscopy. Compared to original CFs, the load quantity of CipHCl into the click product was greatly increased, the release time of CipHCl from CFs-N₃@Pro-β-CD was prolonged, and considerably higher antibacterial activity against E. coli and S. aureus was observed. The click product exhibited excellent antibacterial activity and sustained antibacterial efficacy up to 12 and 10 days against S. aureus and E. coli. The results showed that β-CD has been successfully grafted onto CFs via covalent bonds, while maintaining the intrinsic properties and the integrity of the fibers. Compared with the control paper sheet, the mechanical properties of the paper are well preserved.

Graphic abstract

中文翻译：

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通过点击化学开发的环糊精和纤维素组合产品：包含环丙沙星的引人入胜的设计

摘要

在当前的研究中，我们将“点击化学”作为一种强大的工具来定制环糊精-纤维素组合产品，然后加入盐酸环丙沙​​星（CipHCl）作为抗菌剂。最初，对β-环糊精（β-CD）和纤维素纤维（CFs）进行了改性，使其成为单-6-炔丙基氨基-6-脱氧β-CD（Pro-β-CD）和叠氮化纤维素纤维（CFs-N ₃）。之后，在Pro-β-CD和CFs-N ₃之间进行“点击反应”，以将β-CD共价接枝到CF上，从而产生点击产物（CFs-N ₃@Pro-β-CD）。通过将样品浸入水溶液中来执行负载的CipHCl的药物传递动力学，并通过UV光谱法测量CipHCl的吸附和释放量随时间的变化。与原始CF相比，CipHCl在点击产品中的负载量大大增加，CipHCl从CFs-N ₃ @Pro-β-CD释放的时间延长，并且对大肠杆菌和金黄色葡萄球菌的抗菌活性大大提高。被观测到。该点击产品对金黄色葡萄球菌和大肠杆菌具有出色的抗菌活性和长达12天和10天的持续抗菌功效。。结果表明，β-CD已通过共价键成功接枝到CF上，同时保持了纤维的固有特性和完整性。与对照纸张相比，纸张的机械性能得到了很好的保留。

图形摘要