Glioma is the most common primary brain tumor and the most malignant type of glioma is glioblastoma with the character of high mortality, high recurrence rate and poor prognosis. MicroRNAs act as an important component in glioma development and thus may be a potential target for the treatment of glioma. There were some researches indicated that miR-210-3p played a role in glioma development, but if it can inhibit glioma growth, as well as the underlying mechanism, is still uncertain. In the present study, we investigated the effects of miR-210-3p and its potential target gene Iscu on glioma (C6) cells proliferation and migration in vitro as well as the influence of miR-210-3p on glioma growth in vivo. The results showed that miR-210-3p inhibited the proliferation and migration of C6 cells by regulating the expression of its target gene Iscu in vitro. We also demonstrated that glioma growth was suppressed in immunodeficient mice when they were implanted with C6 cells overexpressing miR-210-3p. Our data indicated that miR-210-3p played an important role in the prevention of glioma growth by targeting Iscu and so miR-210-3p/Iscu axis might be a potential target for the treatment of glioma.

中文翻译：

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MiR-210-3p通过靶向Iscu抑制C6细胞的增殖和迁移。

胶质瘤是最常见的原发性脑肿瘤，最恶性的胶质瘤是胶质母细胞瘤，具有高死亡率，高复发率和不良预后的特点。微小RNA在神经胶质瘤发展中起重要作用，因此可能成为神经胶质瘤治疗的潜在靶标。有研究表明，miR-210-3p在神经胶质瘤的发展中起一定作用，但能否抑制神经胶质瘤的生长及其潜在机制尚不清楚。在本研究中，我们研究了miR-210-3p及其潜在靶基因Iscu对神经胶质瘤（C6）细胞在体外的增殖和迁移的影响，以及miR-210-3p对体内胶质瘤生长的影响。结果表明，miR-210-3p通过在体外调节其靶基因Iscu的表达来抑制C6细胞的增殖和迁移。我们还证明，当免疫缺陷小鼠植入过表达miR-210-3p的C6细胞时，它们会抑制神经胶质瘤的生长。我们的数据表明，miR-210-3p通过靶向Iscu在预防神经胶质瘤生长中发挥了重要作用，因此miR-210-3p / Iscu轴可能是治疗神经胶质瘤的潜在靶标。