The woven bone created during the healing of bone regeneration processes is characterized as being extremely inhomogeneous and having a variable stiffness that increases with time. Therefore, it is important to study how the mechanical properties of woven bone are dependent on its microarchitecture and especially on its porosity and mineral content. The porosity and the x-ray greyscale of specimens taken from bone transport studies in sheep were assessed by means of ex vivo imaging. Our study demonstrates that the porosity of the woven bone in the distraction area diminishes during the healing process from 73.3% 35 days after surgery to 31.9% 525 days after surgery. In addition, the woven bone's porosity is negatively correlated with its Young's modulus. The x-ray greyscale, was measured as an indicator of the level of mineralization of the woven bone. Greyscale index has been demonstrated to be inversely proportional to porosity and to increase to up to 60-80% of the level in cortical bone. The results of this study may contribute to the development of micromechanical models of woven bone and improvements in in silico modelling.

中文翻译：

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编织骨的弹性模量：与孔隙率和 X 射线灰度演变的相关性。

在骨再生过程的愈合过程中产生的编织骨的特征是极其不均匀，并且具有随时间增加的可变刚度。因此，重要的是研究编织骨的机械性能如何取决于其微结构，尤其是其孔隙率和矿物质含量。取自绵羊骨转运研究的样本的孔隙率和 X 射线灰度通过离体成像进行评估。我们的研究表明，在愈合过程中，牵引区编织骨的孔隙率从术后 35 天的 73.3% 减少到术后 525 天的 31.9%。此外，编织骨的孔隙率与其杨氏模量呈负相关。X 射线灰度，测量作为编织骨矿化水平的指标。灰度指数已被证明与孔隙率成反比，并增加到皮质骨水平的 60-80%。这项研究的结果可能有助于编织骨微机械模型的发展和硅建模的改进。