OBJECTIVES This study aimed to measure the global brain glucose metabolism of patients with temporal lobe epilepsy (TLE) using MIMneuro software based on the normal brain glucose metabolism database. METHODS In this cross-sectional study, 23 patients (11 males and 12 females, mean age 25.6 ± 10.1 years) with TLE who underwent 18F-labeled fluoro-2-deoxyglucose positron emission tomography (18F-FDG PET) were enrolled. 18F-FDG PET images were then imported into MIMneuro software, which can automatically analyze the differences in regional brain glucose metabolism between patients and a normal database, and the results of different brain regions were presented by values of Z-score. RESULTS In patients with TLE, 18F-FDG PET imaging showed that in addition to the presence of temporal lobe hypometabolism, there was hypometabolism in the ipsilateral hippocampus, parahippocampal gyrus, insula, amygdala, temporal operculum, and bilateral cerebellar hemisphere, while hypermetabolism was found in the contralateral temporal lobe, frontal lobe, parietal lobe, parietal lobule, angular gyrus, and precentral gyrus. There was no significant difference in brain areas between the left and the right temporal lobe seizures (P > 0.05). CONCLUSIONS We found that TLE has a specific characteristic in terms of brain glucose metabolism, and the underlying mechanism needs to be further studied that may be helpful to localize seizure focus.

中文翻译：

---

使用正常18F-FDG PET数据库识别颞叶癫痫患者的脑葡萄糖代谢特征。

目的本研究旨在使用基于正常脑葡萄糖代谢数据库的MIMneuro软件来测量颞叶癫痫（TLE）患者的整体脑葡萄糖代谢。方法在这项横断面研究中，纳入了接受18F标记的氟-2-脱氧葡萄糖正电子发射断层显像（18F-FDG PET）的TLE患者23例（男11例，女12例，平均年龄25.6±10.1岁）。然后将18F-FDG PET图像导入MIMneuro软件，该软件可以自动分析患者与正常数据库之间区域性脑葡萄糖代谢的差异，并通过Z值显示不同脑区的结果。结果在TLE患者中，18F-FDG PET成像显示，除了颞叶代谢不足外，同侧海马，海马旁回，岛，杏仁核，颞小oper和双侧小脑半球均存在低代谢，而对侧颞叶，额叶，顶叶，顶小叶，角回和中央前回均有代谢亢进。左侧和右侧颞叶癫痫发作的大脑区域没有显着差异（P> 0.05）。结论我们发现TLE在脑葡萄糖代谢方面具有特定的特征，其潜在机制有待进一步研究，可能有助于定位癫痫发作的重点。角回和中央前回。左侧和右侧颞叶癫痫发作之间的大脑区域没有显着差异（P> 0.05）。结论我们发现TLE在脑葡萄糖代谢方面具有特定的特征，其潜在机制有待进一步研究，可能有助于定位癫痫发作的重点。角回和中央前回。左侧和右侧颞叶癫痫发作之间的大脑区域没有显着差异（P> 0.05）。结论我们发现TLE在脑葡萄糖代谢方面具有特定的特征，其潜在机制有待进一步研究，可能有助于定位癫痫发作的重点。