The complete genome sequence of Lactobacillus paracasei DTA93, isolated from healthy infant feces is reported, along with in silico genetic analyses of its main features. The 3.02 Mb sequenced genome possesses 2990 protein-coding sequences distributed on 341 SEED subsystems. In previous in vitro studies, this strain demonstrated interesting probiotic properties, anti-cancer activity, and anti-bacterial activity. The whole-genome sequencing allowed to identify DTA93 as L. paracasei and to precisely place it within the L. casei group, since it shows the highest number of orthologous genes/proteins in common with the type strain L. paracasei ATCC 25302 T . In silico analyses revealed the absence of potentially negative traits, such as presence of prophages, transmissible antibiotic resistance and virulence factors. The results provided here considerably increased the amount of information available on DTA93 in favor of its possible use in food products as health-promoting culture. The complete genome data have been deposited in GenBank under the accession number VTYT00000000.

中文翻译：

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副干酪乳杆菌 DTA93 的全基因组序列和比较基因组分析，一种有前途的益生菌乳酸菌

报告了从健康婴儿粪便中分离的副干酪乳杆菌 DTA93 的完整基因组序列，以及对其主要特征的计算机遗传分析。3.02 Mb 测序的基因组拥有分布在 341 个 SEED 子系统上的 2990 个蛋白质编码序列。在之前的体外研究中，该菌株表现出有趣的益生菌特性、抗癌活性和抗菌活性。全基因组测序允许将 DTA93 鉴定为副干酪乳杆菌并将其精确地置于干酪乳杆菌组中，因为它显示了与类型菌株副干酪乳杆菌 ATCC 25302 T 相同的最高数量的直系同源基因/蛋白质。计算机分析显示不存在潜在的负面特征，例如存在原噬菌体、可传播的抗生素耐药性和毒力因子。此处提供的结果大大增加了有关 DTA93 的可用信息量，有利于其在食品中作为促进健康的文化的可能用途。完整的基因组数据已存入GenBank，登录号为VTYT00000000。