We studied the role of opioid receptor subtypes in improvement of the functional state of the heart during reperfusion after adaptation to continuous normobaric hypoxia. To this end, male Wistar rats were subjected to continuous normobaric hypoxia (12% O 2 ). Then, the hearts were isolated and exposed to total 45-min ischemia followed by 30-min reperfusion. Opioid receptor antagonists were added to the perfusion solution prior to ischemia. It was found that continuous normobaric hypoxia reduced the release of creatine phosphokinase into the effluent, increased myocardial contractile force, and decreased the end-diastolic pressure during reperfusion; these positive effects were related to activation of cardiac δ 2 - and μ-opioid receptors.

中文翻译：

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心脏阿片受体在持续常压缺氧心脏保护作用中的作用

我们研究了阿片受体亚型在适应持续常压缺氧后在再灌注期间改善心脏功能状态中的作用。为此，雄性 Wistar 大鼠经受持续的常压缺氧 (12% O 2 )。然后，分离心脏并暴露于总缺血 45 分钟，然后再灌注 30 分钟。在缺血前将阿片受体拮抗剂加入灌注溶液中。研究发现，持续的常压缺氧减少了肌酸磷酸激酶释放到流出液中，增加了心肌收缩力，降低了再灌注过程中的舒张末期压力；这些积极作用与心脏δ 2 - 和μ-阿片受体的激活有关。