The use of induced pluripotent stem cells (IPSC) is a promising approach to the therapy of CNS diseases. The undeniable advantage of IPSC technology is the possibility of obtaining practically all types of somatic cells for autologous transplantation bypassing bioethical problems. The review presents integrative and non-integrative methods for obtaining IPSC and the ways of their in vitro and in vivo application for the study and treatment of neurological diseases.

中文翻译：

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诱导多能干细胞的产生方法及其在治疗中枢神经系统疾病中的应用

诱导多能干细胞 (IPSC) 的使用是治疗 CNS 疾病的一种很有前景的方法。IPSC 技术不可否认的优势是获得几乎所有类型的体细胞用于自体移植绕过生物伦理问题的可能性。该综述介绍了获取 IPSC 的综合和非综合方法，以及它们在体外和体内应用于神经系统疾病研究和治疗的方法。