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Methods of Generation of Induced Pluripotent Stem Cells and Their Application for the Therapy of Central Nervous System Diseases

  • Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

The use of induced pluripotent stem cells (IPSC) is a promising approach to the therapy of CNS diseases. The undeniable advantage of IPSC technology is the possibility of obtaining practically all types of somatic cells for autologous transplantation bypassing bioethical problems. The review presents integrative and non-integrative methods for obtaining IPSC and the ways of their in vitro and in vivo application for the study and treatment of neurological diseases.

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Authors and Affiliations

  1. Federal Center for Cerebrovascular Pathology and Stroke, Ministry of Health of Russian Federation, Moscow, Russia

    E. A. Cherkashova, A. A. Solov’eva, I. L. Gubskii & L. V. Gubskii

  2. N. P. Bochkov Research Center for Medical Genetics, Moscow, Russia

    G. E. Leonov, T. B. Bukharova & D. V. Goldstein

  3. N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russian Federation, Moscow, Russia

    D. D. Namestnikova & L. V. Gubskii

  4. V. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia

    K. N. Yarygin

  5. Russian Medical Academy for Continuous Professional Education, Ministry of Health of the Russian Federation, Moscow, Russia

    K. N. Yarygin

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  1. E. A. Cherkashova
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  2. G. E. Leonov
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  3. D. D. Namestnikova
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  4. A. A. Solov’eva
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  5. I. L. Gubskii
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  6. T. B. Bukharova
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  7. L. V. Gubskii
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  9. K. N. Yarygin
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Correspondence to G. E. Leonov.

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Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 4, pp. 253-261, December, 2019

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Cherkashova, E.A., Leonov, G.E., Namestnikova, D.D. et al. Methods of Generation of Induced Pluripotent Stem Cells and Their Application for the Therapy of Central Nervous System Diseases. Bull Exp Biol Med 168, 566–573 (2020). https://doi.org/10.1007/s10517-020-04754-4

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