Pluripotency in stem cells is regulated by a complex network between the transcription factors, signaling molecules, mRNAs, and epigenetic regulators like non-coding RNAs. Different pluripotent stem cell (PSC) lines were isolated and characterized to study the regulatory network topology to understand the mechanism that control developmental potential of pluripotent cells. PSCRIdb is a manually curated database of regulatory interactions including protein–protein, protein–DNA, gene–gene, and miRNA–mRNA interactions in mouse and human pluripotent stem cells including embryonic stem cells and embryonic carcinoma cells. At present, 22 different mouse and human pluripotent stem-cell-line-specific regulatory interactions are compiled in the database. Detailed information of the four types of interaction data are presented in tabular format and graphical network view in Cytoscape layout. The database is available at http://bicresources.jcbose.ac.in/ssaha4/pscridb . The database contains 3037 entries of experimentally validated molecular interactions that can be useful for systematic study of pluripotency integrating multi-omics data. In summary, the database can be a useful resource for identification of regulatory networks present in different pluripotent stem cell lines.

中文翻译：

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PSCRIdb：多能干细胞系的调节相互作用和网络数据库

干细胞的多能性受转录因子、信号分子、mRNA 和表观遗传调节因子（如非编码 RNA）之间的复杂网络的调控。分离并表征了不同的多能干细胞 (PSC) 系，以研究调节网络拓扑结构，以了解控制多能细胞发育潜力的机制。PSCRIdb 是一个手动管理的调控相互作用数据库，包括小鼠和人类多能干细胞（包括胚胎干细胞和胚胎癌细胞）中的蛋白质-蛋白质、蛋白质-DNA、基因-基因和 miRNA-mRNA 相互作用。目前，数据库中汇编了 22 种不同的小鼠和人类多能干细胞系特异性调节相互作用。这四种交互数据的详细信息以表格格式和 Cytoscape 布局中的图形网络视图呈现。该数据库可从 http://bicresources.jcbose.ac.in/ssaha4/pscridb 获得。该数据库包含 3037 个经过实验验证的分子相互作用条目，可用于整合多组学数据的多能性系统研究。总之，该数据库可以成为识别不同多能干细胞系中存在的调节网络的有用资源。