Aging is a natural biological process that results in progressive loss of cell, tissue, and organ function. One of the causing factors of the aging process is the decrease in muscle mass, which has not been fully verified in Drosophila. Apoptotic cell death may result in aberrant cell loss and can eventually diminish tissue function and muscle atrophy. If so, inhibition of apoptosis may prolong longevity and reduce motor function and muscle mass decline with age in Drosophila flies. Here, we used Drosophila melanogaster as study material, and induced the overexpression of Drosophila inhibitor of apoptosis protein 1 gene to inhibit apoptosis, and investigated the effect of apoptosis inhibition on the longevity and age-related declines in flight and climbing ability and muscle mass. As a result, the inhibition of apoptosis tended to mitigate the aging effects and prolonged longevity and reduced climbing ability decline with age. The current study suggests that apoptosis inhibition could mitigate the aging effects in D. melanogaster. Although such effects have already been known in mammals, the current results suggest that the apoptosis may play a similar role in insects as well.

中文翻译：

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细胞凋亡抑制减轻黑腹果蝇的衰老作用

衰老是一种自然的生物过程，会导致细胞、组织和器官功能的逐渐丧失。导致衰老过程的因素之一是肌肉质量的减少，这在果蝇中尚未得到充分验证。凋亡细胞死亡可能导致异常细胞损失，并最终会削弱组织功能和肌肉萎缩。如果是这样，抑制细胞凋亡可能会延长寿命并减少果蝇的运动功能和肌肉质量随年龄增长而下降。在这里，我们以黑腹果蝇为研究材料，诱导果蝇凋亡抑制蛋白 1 基因的过度表达来抑制细胞凋亡，并研究了细胞凋亡抑制对寿命和与年龄相关的飞行和攀爬能力下降和肌肉质量的影响。因此，细胞凋亡的抑制趋向于减轻衰老效应，延长寿命并降低攀爬能力随年龄增长而下降。目前的研究表明，抑制细胞凋亡可以减轻黑腹果蝇的衰老效应。虽然在哺乳动物中已经知道这种影响，但目前的结果表明细胞凋亡也可能在昆虫中发挥类似的作用。