In our study, we focused on possible effects of supplementation with glucan and vitamin D on total numbers of NK cells in patients with diabetic retinopathy. We evaluated possible relations among nutritional state (BMI), leptin levels, and total numbers of NK cells in patients supplemented with (1) glucan and vitamin D, (2) vitamin D and placebo, and (3) vitamin D alone. Our results show that 3 months of supplementation with both glucan and vitamin D resulted in significant improvements of NK cell numbers. In addition, we found statistically significant correlation between NK cell numbers and leptin levels. Based on these results, we propose that the molecule responsible for these changes is glucan, as vitamin D alone or together with placebo caused no effects.

在我们的研究中，我们集中研究了补充葡聚糖和维生素D对糖尿病性视网膜病变患者NK细胞总数的可能影响。我们评估了补充（1）葡聚糖和维生素D，（2）维生素D和安慰剂以及（3）维生素D的患者的营养状态（BMI），瘦素水平和NK细胞总数之间的可能关系。我们的结果表明，同时添加3个月的葡聚糖和维生素D可以显着改善NK细胞的数量。此外，我们发现NK细胞数量与瘦素水平之间存在统计学上的显着相关性。根据这些结果，我们认为负责这些变化的分子是葡聚糖，因为单独使用维生素D或与安慰剂一起使用不会造成任何影响。