γ-Carboline derivatives were synthesized by the addition of fluorinated vinylpyridines to 2,6-dimethyl-2,3,4,5-tetrahydro-γ-carboline. The effect of repeated intraperitoneal injections of the synthesized derivatives on the progression of motor and cognitive dysfunctions was studied in comparison with Dimebon in 5xFAD transgenic mice as a model of neurodegenerative diseases induced by cerebral amyloidosis.

中文翻译：

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氟化γ-咔啉作为延迟神经退行性疾病转基因模型中认知和运动功能障碍的药物

γ-咔啉衍生物是通过将氟化乙烯基吡啶加成到 2,6-二甲基-2,3,4,5-四氢-γ-咔啉中来合成的。在作为脑淀粉样变性诱发的神经退行性疾病模型的 5xFAD 转基因小鼠中，与 Dimebon 相比，研究了重复腹膜内注射合成衍生物对运动和认知功能障碍进展的影响。