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Fluorinated γ-carbolines as agents for delaying cognitive and motor dysfunctions in a transgenic model of neurodegenerative disorders

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Abstract

γ-Carboline derivatives were synthesized by the addition of fluorinated vinylpyridines to 2,6-dimethyl-2,3,4,5-tetrahydro-γ-carboline. The effect of repeated intraperitoneal injections of the synthesized derivatives on the progression of motor and cognitive dysfunctions was studied in comparison with Dimebon in 5xFAD transgenic mice as a model of neurodegenerative diseases induced by cerebral amyloidosis.

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Authors and Affiliations

  1. Institute of Physiologically Active Compounds, Russian Academy of Sciences, 1 Severnyi proezd, 142432, Chernogolovka, Moscow Region, Russian Federation

    A. A. Ustyugov, A. Yu. Aksinenko, Yu. B. Vikharev, G. V. Maleev, V. O. Nebogatikov, N. A. Vasil’eva, E. F. Shevtsova & S. O. Bachurin

Authors
  1. A. A. Ustyugov
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  2. A. Yu. Aksinenko
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  3. Yu. B. Vikharev
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  4. G. V. Maleev
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  5. V. O. Nebogatikov
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  6. N. A. Vasil’eva
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  7. E. F. Shevtsova
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  8. S. O. Bachurin
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Corresponding author

Correspondence to A. A. Ustyugov.

Additional information

This work was financially supported by the Russian Science Foundation (Project No. 19-13-00378; synthesis of compounds) and the Presidium of the Russian Academy of Sciences (Program “Innovative Developments in Biomedicine;” behavioral bioassays). Transgenic animals were housed and phenotypically characterized within the framework of the State assignment to the Institute of Physiologically Active Compounds of the Russian Academy of Sciences (Program No. 0090-2019-0005) using facilities of the Multiple-access Center of this Institute.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 4, pp. 0781–0786, April, 2020.

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Ustyugov, A.A., Aksinenko, A.Y., Vikharev, Y.B. et al. Fluorinated γ-carbolines as agents for delaying cognitive and motor dysfunctions in a transgenic model of neurodegenerative disorders. Russ Chem Bull 69, 781–786 (2020). https://doi.org/10.1007/s11172-020-2833-4

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  • DOI: https://doi.org/10.1007/s11172-020-2833-4

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