In this current work, gold nanoparticles (AuNPs) were used to attenuate the brain dysfunction in experimental model of diabetes. Microwave radiation technique was utilized in the production of AuNPs. Afterward, 40 male albino rats were consumed in this study and divided into five groups: control, diabetic, diabetic administered only dextran, diabetic administered AuNPs in a dose of 1 mg/kg body weight in aqueous solution/day, and diabetic administered AuNPs in a dose of 2 mg/kg body weight in aqueous solution/day. In addition, brain neurotransmitters and cholinesterase activity were also evaluated. Results: In diabetic group, diabetes complications were appeared in elevation of oxidative stress parameters and pro inflammatory markers, in addition to disturbances of neurotransmitters as well as cholinesterase activity, however in treated groups, AuNPs significantly controlled all these hazardous induced by induction of diabetes. In conclusion, AuNPs appeared as a promising agent, that has the ability to augment neuronal damage and brain dysfunction appeared during diabetes mellitus. Additionally, the high dose (2 mg/kg body weight) appeared more potent than the lower dose (1 mg/kg body weight) in attenuating diabetic complications during experimental diabetes.

在这项当前的工作中，金纳米颗粒（AuNPs）用于减轻糖尿病实验模型中的脑功能障碍。微波辐射技术被用于生产AuNPs。此后，本研究消耗了40只雄性白化病大鼠，分为5组：对照组，糖尿病，仅给予右旋糖酐的糖尿病，每天以水溶液1 mg / kg体重的剂量向糖尿病给药的AuNPs和向糖尿病的大鼠给药AuNPs。水溶液中每天2 mg / kg体重的剂量。此外，还评估了脑神经递质和胆碱酯酶活性。结果：在糖尿病组中，除了神经递质紊乱和胆碱酯酶活性异常外，糖尿病并发症还包括氧化应激参数和促炎性标志物升高，但是，AuNPs可以有效控制所有由糖尿病诱发的危害。总之，AuNPs有望成为一种有前途的药物，它具有增强糖尿病期间出现神经元损伤和脑功能障碍的能力。此外，在减轻实验性糖尿病患者的糖尿病并发症方面，高剂量（2 mg / kg体重）似乎比低剂量（1 mg / kg体重）更有效。