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Eco-friendly Microwave Synthesis of Gold Nanoparticles for Attenuation of Brain Dysfunction in Diabetic Rats

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Abstract

In this current work, gold nanoparticles (AuNPs) were used to attenuate the brain dysfunction in experimental model of diabetes. Microwave radiation technique was utilized in the production of AuNPs. Afterward, 40 male albino rats were consumed in this study and divided into five groups: control, diabetic, diabetic administered only dextran, diabetic administered AuNPs in a dose of 1 mg/kg body weight in aqueous solution/day, and diabetic administered AuNPs in a dose of 2 mg/kg body weight in aqueous solution/day. In addition, brain neurotransmitters and cholinesterase activity were also evaluated. Results: In diabetic group, diabetes complications were appeared in elevation of oxidative stress parameters and pro inflammatory markers, in addition to disturbances of neurotransmitters as well as cholinesterase activity, however in treated groups, AuNPs significantly controlled all these hazardous induced by induction of diabetes. In conclusion, AuNPs appeared as a promising agent, that has the ability to augment neuronal damage and brain dysfunction appeared during diabetes mellitus. Additionally, the high dose (2 mg/kg body weight) appeared more potent than the lower dose (1 mg/kg body weight) in attenuating diabetic complications during experimental diabetes.

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Acknowledgements

This research was funded by the Deanship of Scientific Research at Princess Nourah bint Abdulrahman University through the Fast-track Research Funding Program.

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Authors and Affiliations

  1. Medical Biochemistry Department, National Research Centre, 33 El-Behooth St., Dokki, Giza, 12311, Egypt

    Jihan Hussein

  2. Textile Industries Research Division, Pre-Treatment and Finishing of Cellulosic Based Fibers Department, National Research Centre, 33 El-Behooth St, Dokki, Giza, 12311, Egypt

    Mehrez E. El-Naggar & Moustafa M. G. Fouda

  3. Biology Department, College of Science, Princess Nourah Bint Abdulrahman University, BO. Box 24428, Riyadh, 11671, Saudi Arabia

    Sarah I. Othman

  4. Department of Zoology, Faculty of Science, Beni-suef University, Beni Suef, 65211, Egypt

    Ahmed A. Allam

  5. Department of Pharmacology, College of Medicine, Jouf University, Sakaka, Saudi Arabia

    Eman H. Nadwa

  6. Department of Medical Pharmacology, Faculty of Medicine, Cairo University, Cairo, Egypt

    Eman H. Nadwa

  7. Department of Physiology, College of Medicine, Jouf University, Sakaka, Saudi Arabia

    Eman K. Rashwan

  8. Department of Physiology, Faculty of Medicine, Al-Azhar University, Asyut, Egypt

    Eman K. Rashwan

  9. Faculty of Pharmacy, Jouf University, Sakaka, Saudi Arabia

    O. M. Hendawy

  10. Clinical Pharmacology, Faculty of Medicine, Beni-Suef University, Beni Suef, Egypt

    O. M. Hendawy

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  1. Jihan Hussein
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Correspondence to Mehrez E. El-Naggar or Moustafa M. G. Fouda.

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Hussein, J., El-Naggar, M.E., Fouda, M.M.G. et al. Eco-friendly Microwave Synthesis of Gold Nanoparticles for Attenuation of Brain Dysfunction in Diabetic Rats. J Clust Sci 32, 423–435 (2021). https://doi.org/10.1007/s10876-020-01801-y

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