Ni-EDTA modified nano-magnetite Fe₃O₄ with shell silica-MCM-41 (Fe₃O₄@Si-MCM-41@EDTA@Ni) was designed using a post-grafting process and utilized as an effective, novel, and magnetic heterogeneous recoverable nano-catalyst in the clean production of 2,3-dihydroquinazolin-4(1H)-ones through cyclo-condensation. The structure of nano-catalyst was analyzed by TEM, TGA, XRD, FT-IR, EDS, SEM, VSM, ICP-AES tools and hot filtration test. The heterogeneous nanostructured Fe₃O₄@Si-MCM-41@EDTA@Ni with the saturation magnetization values 15.2 emu g⁻¹ indicated great recyclability and could be easily reutilized for seven successive times no considerable decrease in its catalytic efficiency and activity. The desirable result was obtained with 1.0 mmol of 2-aminobenzamide and aldehyde in the existence of Fe₃O₄@MCM-41@APTES@EDTA@Ni (5 mg) and EtOH (4 ml) as clean solvent at reflux. Also, various aldehydes could smoothly participate in the cyclo-condensation reaction and produce quinazoline compounds with good yields %76–95.

采用后接枝工艺设计了具有壳二氧化硅-MCM-41的Ni-EDTA改性纳米磁铁矿Fe ₃ O ₄（Fe ₃ O ₄ @ Si-MCM-41 @ EDTA @ Ni），并被用作一种有效的，新颖的，环缩合反应清洁生产2,3-二氢喹唑啉-4（1 H）-ones的磁性非均相可回收纳米催化剂。通过TEM，TGA，XRD，FT-IR，EDS，SEM，VSM，ICP-AES工具和热过滤试验分析了纳米催化剂的结构。饱和磁化值为15.2 emu g ^-1的异质纳米结构Fe ₃ O ₄ @ Si-MCM-41 @ EDTA @ Ni表明其具有很好的可回收性，可以很容易地连续七次重复使用，其催化效率和活性没有明显降低。在回流下，在存在Fe ₃ O ₄ @ MCM-41 @ APTES @ EDTA @ Ni（5mg）和EtOH（4ml）作为清洁溶剂的情况下，用1.0mmol的2-氨基苯甲酰胺和醛获得了期望的结果。同样，各种醛类可以顺利地参与环缩合反应，并生成喹唑啉化合物，收率％76-95。