Objective: Osteosarcoma is considered as one of the most common types of bone tumors, which occurs among adolescents and children.

Methods: Current therapy strategies still have limited effectiveness therefore, the development of new therapies is urgent. Morusin is a compound isolated from Morus australis (Moraceae). Many studies have reported its anti-tumor effect on several tumor types. However, its role in osteosarcoma is still unclear.

Results: In this study, we determined that morusin significantly suppresses the proliferation and promotes the apoptosis of osteosarcoma cells. Furthermore, the migration and invasion of osteosarcoma were reduced after exposure to morusin. The deep mechanism was determined to be the inhibition of the PI3K/AKT signaling pathway.

Conclusion: In conclusion, our study indicates morusin as a potential candidate for osteosarcoma therapy.

目的：骨肉瘤被认为是最常见的骨肿瘤类型之一，多发于青少年和儿童。

方法：目前的治疗策略仍然有限，因此，新疗法的开发迫在眉睫。桑树素是从澳洲桑树（桑科）中分离的化合物。许多研究报告了其对几种肿瘤类型的抗肿瘤作用。但是，其在骨肉瘤中的作用仍不清楚。

结果：在这项研究中，我们确定了毛蛋白显着抑制骨肉瘤细胞的增殖并促进其凋亡。此外，暴露于莫鲁辛后，骨肉瘤的迁移和侵袭减少。确定该深层机制是对PI3K / AKT信号传导途径的抑制。

结论：总而言之，我们的研究表明莫鲁辛可能是骨肉瘤治疗的潜在候选者。