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Current Pharmaceutical Biotechnology

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ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

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General Research Article

Morusin Inhibits Human Osteosarcoma via the PI3K-AKT Signaling Pathway

Author(s): Yong Zhang, Qiuyan Weng, Jianming Chen and Jinming Han*

Volume 21, Issue 13, 2020

Page: [1402 - 1409] Pages: 8

DOI: 10.2174/1389201021666200416093457

Price: $65

Abstract

Objective: Osteosarcoma is considered as one of the most common types of bone tumors, which occurs among adolescents and children.

Methods: Current therapy strategies still have limited effectiveness therefore, the development of new therapies is urgent. Morusin is a compound isolated from Morus australis (Moraceae). Many studies have reported its anti-tumor effect on several tumor types. However, its role in osteosarcoma is still unclear.

Results: In this study, we determined that morusin significantly suppresses the proliferation and promotes the apoptosis of osteosarcoma cells. Furthermore, the migration and invasion of osteosarcoma were reduced after exposure to morusin. The deep mechanism was determined to be the inhibition of the PI3K/AKT signaling pathway.

Conclusion: In conclusion, our study indicates morusin as a potential candidate for osteosarcoma therapy.

Keywords: Morusin, osteosarcoma, PI3K/AKT, therapy, MMPs, human osteosarcoma.

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