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Development of Blood Compatible Composite Using MPC Copolymer and Polyolefin for Non-PVC Blood Bag Application
Macromolecular Research ( IF 2.8 ) Pub Date : 2019-12-10 , DOI: 10.1007/s13233-020-8047-7
Seung Kyun Yoon , Dong June Chung

Polyolefin is a good candidate for a blood bag material alternative to the poly (vinyl chloride) (PVC) blood bag that contains di-2-ethylhexyl phthalate (DEHP). However, polyolefin readily adsorbs some plasma proteins and platelets. To prevent these undesired adsorption, 2-methacryloyloxyethyl phosphorylcholine (MPC) — hydroxyethyl methacrylate (HEMA) — lauryl methacrylate (LMA) copolymers with varying monomer ratios were synthesized and used as blended material for additives to reduce platelet adsorption. Platelet adsorptive properties were reduced by blending MPC copolymers with polyolefin and confirmed by the platelet adhesion test and the activated partial thromboplastin time (APTT) test.


中文翻译:

MPC共聚物和聚烯烃在非PVC血袋中的血液相容性复合材料的开发

聚烯烃是替代包含邻苯二甲酸二-2-乙基己酯(DEHP)的聚氯乙烯(PVC)血袋的血袋材料的良好候选者。但是,聚烯烃容易吸附一些血浆蛋白和血小板。为了防止这些不希望的吸附,合成了具有不同单体比率的2-甲基丙烯酰氧基氧乙基磷酰胆碱(MPC)-甲基丙烯酸羟乙酯(HEMA)-甲基丙烯酸月桂酯(LMA)共聚物,并将其用作降低血小板吸附的添加剂的共混材料。通过将MPC共聚物与聚烯烃共混会降低血小板的吸附性能,并通过血小板粘附试验和活化的部分凝血活酶时间(APTT)试验来证实。
更新日期:2019-12-10
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