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Development of Blood Compatible Composite Using MPC Copolymer and Polyolefin for Non-PVC Blood Bag Application

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Abstract

Polyolefin is a good candidate for a blood bag material alternative to the poly (vinyl chloride) (PVC) blood bag that contains di-2-ethylhexyl phthalate (DEHP). However, polyolefin readily adsorbs some plasma proteins and platelets. To prevent these undesired adsorption, 2-methacryloyloxyethyl phosphorylcholine (MPC) — hydroxyethyl methacrylate (HEMA) — lauryl methacrylate (LMA) copolymers with varying monomer ratios were synthesized and used as blended material for additives to reduce platelet adsorption. Platelet adsorptive properties were reduced by blending MPC copolymers with polyolefin and confirmed by the platelet adhesion test and the activated partial thromboplastin time (APTT) test.

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References

  1. M. Lozano and J. Cid, ISBT Sci. Ser., 8, 127 (2013).

    Article  Google Scholar 

  2. G.-S. Khang, J.-H. Lee, and H.-B. Lee, Polym. Sci. Technol., 7, 312 (1996).

    Google Scholar 

  3. J.-H. Lee, K.-O. Kim, and Y.-M. Ju, Biomed. Mater. Res., 48, 328 (1999).

    Article  CAS  Google Scholar 

  4. B. Maas, C. Hurber, and I. Krämer, Int. J. Clinical Pharm., 18, 78 (1996).

    CAS  Google Scholar 

  5. K.-H. Park, and D.-J. Chung, Biomater. Res., 19, 2 (2015).

    Article  CAS  Google Scholar 

  6. C. V. Prowse, D. de Korte, J. R. Hess, P. F. van der Meer, Vox Sang., 106, 1 (2014).

    Article  CAS  Google Scholar 

  7. K. Ishihara, Y. Iwasaki, and N. Nakabayashi, Mater. Sci. Eng., C6, 253 (1998).

    Article  CAS  Google Scholar 

  8. N. Nakabayashi and D. F. Williams, Biomaterials, 24, 2431 (2003).

    Article  CAS  Google Scholar 

  9. A. L. Lewis, P. D. Hughes, L. C. Kirkwood, S. W. Leppard, R. P. Redman, L. A. Tolhurst, and P. W. Stratford, Biomaterials, 21, 1847 (2000).

    Article  CAS  Google Scholar 

  10. M. Ohshio, K. Ishihara, and S. Yusa, Polymer, 11, 327 (2019).

    Article  CAS  Google Scholar 

  11. B. Barthélémy, S. Maheux, S. Devillers, F. Kanoufi, C. Combellas, J. Delhalle, and Z. Mekhalif, ACS Appl. Mater. Interfaces, 6, 10060 (2014).

    Article  CAS  Google Scholar 

  12. K. Ito, K. Uchida, T. Kitono, E. Yamada, and T. Matsumoto, Polym. J., 17, 761 (1985).

    Article  CAS  Google Scholar 

  13. V. K. Tiwari, P. K. Kulriya, D. K. Avsthi, and P. Maiti, J. Phys. Chem. B, 113, 11632 (2009).

    Article  CAS  Google Scholar 

  14. S.-H. Jeong, S.-Y. Yeo, and S.-C. Yi, J. Mater. Sci., 40, 5407 (2005).

    Article  CAS  Google Scholar 

  15. N. T. Dintcheva, E. Morici, R. Arrigo, and F. P. La Mantia, Polym. J., 46, 160 (2014).

    Article  CAS  Google Scholar 

  16. J.-W. Chon, J.-Y. Lee, Y.-J. Song, J.-H. Kim, and D.-J. Chung, Biomater. Res., 20, 35 (2016).

    Article  CAS  Google Scholar 

  17. E. Pretorius, W. A. Vieira, H. M. Oberholzer, and R. E. J. Auer, Int. J. Morphol., 27, 69 (2009).

    Article  Google Scholar 

  18. J.-Y. Cho, H.-K. Kim, J.-W. Song, J.-W. Cheong, J.-W. Shin, W.-I. Yang, and H.-O. Kim, J. Transl. Med., 16, 199 (2018).

    Article  CAS  Google Scholar 

  19. J. W. Eikelboom, and J. Hirsh, Thromb. Haemost., 96, 547 (2006).

    Article  CAS  Google Scholar 

  20. D. D. Mishra and A. K Bajpai, J. Mater. Sci., Mater. Med., 15, 1921 (2004).

    Google Scholar 

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Authors and Affiliations

  1. School of Chemical Engineering, Sungkyunkwan University, 2066 Seobu-Ro, Jangan-Gu, Suwon, Gyeonggi, 16419, Korea

    Seung Kyun Yoon & Dong June Chung

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  1. Seung Kyun Yoon
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  2. Dong June Chung
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Correspondence to Dong June Chung.

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Acknowledgments: This research was supported by the Basic Science Research Program through the National Research Foundation (NRF) of Korea funded by the Ministry of Science and ICT (Grant No. 2017R1D1A1B03036105).

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Yoon, S.K., Chung, D.J. Development of Blood Compatible Composite Using MPC Copolymer and Polyolefin for Non-PVC Blood Bag Application. Macromol. Res. 28, 319–326 (2020). https://doi.org/10.1007/s13233-020-8047-7

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  • DOI: https://doi.org/10.1007/s13233-020-8047-7

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