Several types of biosensors have been developed to detect a wide variety of human diseases. Immunosensors are classified as the most representative of all biosensors. They are based on antibodies that selectively recognize specific analytes and have high specificity and sensitivity. However, there are limitations to the types of substances that can be detected, and it is sometimes difficult to achieve sufficient sensitivity without additional amplification steps. To overcome these problems, novel immunosensors are being developed that combine DNA-based high signal amplification systems. These technologies ameliorate the low sensitivity of existing immunosensors by using DNA probes that can bind directly to targets as bioreceptors or act as signal amplifiers. In this review, we will discuss immunodetection methods that use DNA-based technologies on laboratory-scale and advanced point-of-care testing (POCT) that employ these technologies for high performance analyses.

中文翻译：

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DNA辅助免疫传感器的进展

已经开发了几种类型的生物传感器来检测各种各样的人类疾病。免疫传感器被归类为所有生物传感器中最具代表性的。它们基于选择性识别特定分析物并具有高特异性和敏感性的抗体。但是，可检测物质的种类受到限制，如果没有其他扩增步骤，有时很难获得足够的灵敏度。为了克服这些问题，正在开发结合基于DNA的高信号放大系统的新型免疫传感器。这些技术通过使用可以直接结合靶作为生物受体或充当信号放大器的DNA探针，改善了现有免疫传感器的低灵敏度。在这篇评论中