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Candida Biofilms: An Update on Developmental Mechanisms and Therapeutic Challenges.
Mycopathologia ( IF 3.6 ) Pub Date : 2020-04-10 , DOI: 10.1007/s11046-020-00445-w
Patrícia Pimentel de Barros 1 , Rodnei Dennis Rossoni 1 , Cheyenne Marçal de Souza 1 , Liliana Scorzoni 1 , Juliana De Camargo Fenley 1 , Juliana Campos Junqueira 1
Affiliation  

Fungi of the genus Candida are important etiological agents of superficial and life-threatening infections in individuals with a compromised immune system. One of the main characteristics of Candida is its ability to form highly drug tolerance biofilms in the human host. Biofilms are a dynamic community of multiple cell types whose formation over time is orchestrated by a network of transcription regulators. In this brief review, we provide an update of the processes involved in biofilm formation by Candida spp. (formation, treatment, and control), as well as the transcriptional circuitry that regulates its development and interactions with other microorganisms. Candida albicans is known to build mixed species biofilms with other Candida species and with various other bacterial species in different host niches. Taken together, these properties play a key role in Candida pathogenesis. In addition, this review gathers recent studies with new insights and perspectives for the treatment and control of Candida biofilms.



中文翻译:

念珠菌生物膜:发展机制和治疗挑战的最新进展。

念珠菌真菌是免疫系统受损的个体中表浅和威胁生命的感染的重要病原体。念珠菌的主要特征之一是其在人宿主中形成高度耐药性生物膜的能力。生物膜是多种细胞类型的动态共同体,随着时间的流逝,其形成是由转录调节因子网络精心策划的。在这篇简短的评论中,我们提供了念珠菌属生物膜形成过程的更新。(形成,治疗和控制),以及调节其发育以及与其他微生物相互作用的转录途径。已知白色念珠菌可与其他物种建立混合物种生物膜念珠菌属物种以及不同宿主壁ni中的各种其他细菌物种。综上所述,这些特性在念珠菌的发病机理中起关键作用。此外,本综述收集了有关念珠菌生物膜治疗和控制的新见解和新见解。

更新日期:2020-04-22
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