Abstract

Fungal co-culture is a strategy to induce the production of secondary metabolites by activating cryptic genes. We discovered the production of a new compound, talarodone A (1), along with five known compounds 2–6 in co-culture of Talaromyces pinophilus and Paraphaeosphaeria sp. isolated from soil collected in Miyazaki Prefecture, Japan. Among them, the productions of penicidones C (2) and D (3) were enhanced 27- and sixfold, respectively, by the co-culture. The structure of 3 should be represented as a γ-pyridol form with the reported chemical shifts, but not as a γ-pyridone form, based on DFT calculation.

Graphic abstract

中文翻译：

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真菌共培养Talaromyces pinophilus和Paraphaeosphaeria sp的次生代谢产物的产生。

摘要

真菌共培养是一种通过激活隐性基因来诱导次级代谢产物产生的策略。我们发现了生产的一种新型化合物，talarodone A（的1）中，用5种已知化合物一起2 - 6中的共培养踝节菌属pinophilus和Paraphaeosphaeria藻。分离自日本宫崎县收集的土壤。其中，通过共培养，青苗C（2）和D（3）的产量分别提高了27倍和6倍。基于DFT计算，3的结构应表示为具有报告的化学位移的γ-吡啶醇形式，而不是γ-吡啶酮形式。

图形摘要