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Intracellular self-assembly of supramolecular gelators to selectively kill cells of interest
Polymer Journal ( IF 2.3 ) Pub Date : 2020-04-13 , DOI: 10.1038/s41428-020-0335-8
Tatsuo Maruyama , Witta Kartika Restu

The significant progress in supramolecular chemistry since the end of last century includes the development of supramolecular gels. In particular, the spatiotemporal self-assembly of synthetic small gelator molecules has attracted increasing attention owing to their ability to achieve certain functional properties in a designated space at a designated time. Peptides conjugated with hydrophobic moieties are typical examples of supramolecular gelators (low molecular weight gelators, LMWGs), which can be designed or programmed to self-assemble to form nanofibers/nanosheets in response to a broad range of stimuli or microenvironments. In the last decade, several groups have reported that the self-assembly of small gelator molecules achieved inside living cells or on the surfaces of living cells induced selective cell death, which would lead to a novel therapeutic approach or a novel cell selection tool. This focused review outlines the self-assembly of small gelator molecules inside living cells that control cell fate. Peptides conjugated with hydrophobic moieties are typical examples of supramolecular gelators (low molecular weight gelators, LMWGs), which can be designed or programmed to self-assemble to form nanofibers/nanosheets in response to stimuli or microenvironments. In the last decade, several groups have reported that the self-assembly of small gelator molecules achieved inside living cells or on the surfaces of living cells induced selective cell death. This focused review outlines the self-assembly of small gelator molecules inside or around living cells that control cell fate.

中文翻译:

超分子凝胶剂的细胞内自组装以选择性杀死感兴趣的细胞

上世纪末以来超分子化学的重大进展包括超分子凝胶的发展。特别是合成小凝胶剂分子的时空自组装由于它们能够在指定时间在指定空间实现某些功能特性而引起越来越多的关注。与疏水部分结合的肽是超分子凝胶剂(低分子量凝胶剂,LMWGs)的典型例子,它可以被设计或编程为自组装以形成纳米纤维/纳米片,以响应广泛的刺激或微环境。在过去的十年中,有几个小组报告说,在活细胞内部或活细胞表面实现的小凝胶分子的自组装诱导了选择性细胞死亡,这将导致一种新的治疗方法或一种新的细胞选择工具。这篇重点综述概述了控制细胞命运的活细胞内小凝胶分子的自组装。与疏水部分结合的肽是超分子凝胶剂(低分子量凝胶剂,LMWGs)的典型例子,它可以被设计或编程为自组装以形成纳米纤维/纳米片以响应刺激或微环境。在过去的十年中,有几个小组报告说,在活细胞内部或活细胞表面上实现的小凝胶剂分子的自组装诱导了选择性细胞死亡。这篇重点综述概述了控制细胞命运的活细胞内部或周围小凝胶分子的自组装。这篇重点综述概述了控制细胞命运的活细胞内小凝胶分子的自组装。与疏水部分结合的肽是超分子凝胶剂(低分子量凝胶剂,LMWGs)的典型例子,它可以被设计或编程为自组装以形成纳米纤维/纳米片以响应刺激或微环境。在过去的十年中,有几个小组报告说,在活细胞内部或活细胞表面上实现的小凝胶剂分子的自组装诱导了选择性细胞死亡。这篇重点综述概述了控制细胞命运的活细胞内部或周围小凝胶分子的自组装。这篇重点综述概述了控制细胞命运的活细胞内小凝胶分子的自组装。与疏水部分结合的肽是超分子凝胶剂(低分子量凝胶剂,LMWGs)的典型例子,它可以被设计或编程为自组装以形成纳米纤维/纳米片以响应刺激或微环境。在过去的十年中,有几个小组报告说,在活细胞内部或活细胞表面上实现的小凝胶剂分子的自组装诱导了选择性细胞死亡。这篇重点综述概述了控制细胞命运的活细胞内部或周围小凝胶分子的自组装。与疏水部分结合的肽是超分子凝胶剂(低分子量凝胶剂,LMWGs)的典型例子,它可以被设计或编程为自组装以形成纳米纤维/纳米片以响应刺激或微环境。在过去的十年中,有几个小组报告说,在活细胞内部或活细胞表面上实现的小凝胶剂分子的自组装诱导了选择性细胞死亡。这篇重点综述概述了控制细胞命运的活细胞内部或周围小凝胶分子的自组装。与疏水部分结合的肽是超分子凝胶剂(低分子量凝胶剂,LMWGs)的典型例子,它可以被设计或编程为自组装以形成纳米纤维/纳米片以响应刺激或微环境。在过去的十年中,有几个小组报告说,在活细胞内部或活细胞表面上实现的小凝胶剂分子的自组装诱导了选择性细胞死亡。这篇重点综述概述了控制细胞命运的活细胞内部或周围小凝胶分子的自组装。几个小组报告说,在活细胞内部或活细胞表面上实现的小凝胶分子的自组装诱导了选择性细胞死亡。这篇重点综述概述了控制细胞命运的活细胞内部或周围小凝胶分子的自组装。几个小组报告说,在活细胞内部或活细胞表面上实现的小凝胶分子的自组装诱导了选择性细胞死亡。这篇重点综述概述了控制细胞命运的活细胞内部或周围小凝胶分子的自组装。
更新日期:2020-04-13
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