Zeolitic imidazolate framework-8 (ZIF-8), composed of Zn ions and imidazolate ligands, is a class of metal-organic frameworks, which possesses a similar structure as conventional aluminosilicate zeolites. This material exhibits inherent porous property, high loading capacity, and pH-sensitive degradation, as well as exceptional thermal and chemical stability. Extensive research effort has been devoted to relevant research aspects ranging from synthesis methods, property characterization to potential applications of ZIF-8. This review focuses on the recent development of ZIF-8 synthesis methods and its promising applications in drug delivery. The potential risks of using ZIF-8 for drug delivery are also summarized.

由锌离子和咪唑化物配体组成的沸石咪唑盐骨架8（ZIF-8）是一类金属有机骨架，其结构与常规铝硅酸盐沸石相似。这种材料具有固有的多孔性，高负载能力和对pH敏感的降解性，以及出色的热稳定性和化学稳定性。从合成方法，性质表征到ZIF-8的潜在应用，广泛的研究工作已投入到相关的研究方面。这篇综述集中在ZIF-8合成方法的最新发展及其在药物递送中的有希望的应用。还总结了使用ZIF-8进行药物递送的潜在风险。