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Zeolitic imidazolate framework-8 (ZIF-8) for drug delivery: A critical review

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Abstract

Zeolitic imidazolate framework-8 (ZIF-8), composed of Zn ions and imidazolate ligands, is a class of metal-organic frameworks, which possesses a similar structure as conventional aluminosilicate zeolites. This material exhibits inherent porous property, high loading capacity, and pH-sensitive degradation, as well as exceptional thermal and chemical stability. Extensive research effort has been devoted to relevant research aspects ranging from synthesis methods, property characterization to potential applications of ZIF-8. This review focuses on the recent development of ZIF-8 synthesis methods and its promising applications in drug delivery. The potential risks of using ZIF-8 for drug delivery are also summarized.

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Acknowledgments

SMF and ZW acknowledge the financial support from the Natural Science Foundation of Tianjin (No. 19JCYBJC28400). XLZ and DYS acknowledge the funding support from the Basic Research General Program of Shenzhen Science and Technology Innovation Commission in 2020.

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Authors and Affiliations

  1. School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, 300072, China

    Simin Feng & Zheng Wang

  2. Central Lab, Shenzhen Second People’s Hospital/The First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, 518035, China

    Xiaoli Zhang

  3. Institute of Hematology, Shenzhen Second People’s Hospital/The First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, 518035, China

    Dunyun Shi

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  1. Simin Feng
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  2. Xiaoli Zhang
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  3. Dunyun Shi
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  4. Zheng Wang
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Correspondence to Zheng Wang.

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Feng, S., Zhang, X., Shi, D. et al. Zeolitic imidazolate framework-8 (ZIF-8) for drug delivery: A critical review. Front. Chem. Sci. Eng. 15, 221–237 (2021). https://doi.org/10.1007/s11705-020-1927-8

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