Luliconazole is a new antifungal that was primarily used for the treatment of dermatophytosis. However, some studies have shown that it has excellent efficacy against Aspergillus and Candida species in vitro. The present study aimed to evaluate of luliconazole activity against some Fusarium species complex isolates. In this study, 47 isolates of Fusarium were tested against several antifungals including luliconazole. All species were identified using morphology features, and PCR sequencing and antifungal susceptibility were performed according to CLSIM38 A3 guideline. Our results revealed that luliconazole has a very low minimum inhibitory concentration value (0.0078–1 µg/ml) in comparison with other tested antifungals. Amphotericin B had a poor effect with a high MIC₉₀ (64 µg/ml), followed by terbinafine (32 µg/ml), posaconazole (16 µg/ml), caspofungin (16 µg/ml), voriconazole (4 µg/ml), and itraconazole (4 µg/ml). Overall, our findings indicated that luliconazole has great activity against environmental and clinical Fusarium species complexes in comparison to tested antifungals.

中文翻译：

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Luliconazole，一种高效的咪唑，对抗镰刀菌属物种的复合物。

卢立康唑是一种新的抗真菌药，主要用于治疗皮肤癣菌病。但是，一些研究表明，它在体外对曲霉和念珠菌具有极好的疗效。本研究旨在评估卢立康唑对某些镰刀菌类复合物分离物的活性。在这项研究中，镰刀菌的47种分离物对包括卢立康唑在内的几种抗真菌药进行了测试。使用形态学特征鉴定所有物种，并根据CLSIM38 A3指南进行PCR测序和抗真菌药敏性。我们的结果表明，与其他经过测试的抗真菌药相比，卢立康唑的最低抑菌浓度值非常低（0.0078-1 µg / ml）。两性霉素B的效果不佳，MIC ₉₀（64 µg / ml）高，其次是特比萘芬（32 µg / ml），泊沙康唑（16 µg / ml），卡泊芬净（16 µg / ml），伏立康唑（4 µg / ml） ）和伊曲康唑（4 µg / ml）。总体而言，我们的研究结果表明，与经测试的抗真菌药相比，卢立康唑对环境和临床镰刀菌物种复合物具有很大的活性。