The nucleosome is a small unit of chromatin, which is dynamic in eukaryotes. Chromatin conformation and post-translational modifications affect nucleosome dynamics under certain conditions, playing an important role in the epigenetic regulation of transcription, replication and reprogramming. The Snf2 remodeling family is one of the crucial remodeling complexes that tightly regulate chromatin structure and affect nucleosome dynamics. This family alters nucleosome positioning, exchanges histone variants, and assembles and disassembles nucleosomes at certain locations. Moreover, the Snf2 family, in conjunction with other co-factors, regulates gene expression in Saccharomyces cerevisiae. Here we first review recent findings on the Snf2 family remodeling complexes and then use some examples to illustrate the cooperation between different members of Snf2 family, and the cooperation between Snf2 family and other co-factors in gene regulation especially during transcription initiation.

中文翻译：

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酵母染色质重塑复合物及其在转录中的作用。

核小体是染色质的一小部分，在真核生物中是动态的。染色质构象和翻译后修饰会在某些条件下影响核小体动力学，在转录，复制和重编程的表观遗传调控中发挥重要作用。Snf2重塑家族是严格调节染色质结构并影响核小体动力学的重要重塑复合体之一。该家族改变核小体的定位，交换组蛋白变体，并在某些位置组装和拆卸核小体。此外，Snf2家族与其他辅因子一起，可调节酿酒酵母中的基因表达。