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Yeast chromatin remodeling complexes and their roles in transcription

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Abstract

The nucleosome is a small unit of chromatin, which is dynamic in eukaryotes. Chromatin conformation and post-translational modifications affect nucleosome dynamics under certain conditions, playing an important role in the epigenetic regulation of transcription, replication and reprogramming. The Snf2 remodeling family is one of the crucial remodeling complexes that tightly regulate chromatin structure and affect nucleosome dynamics. This family alters nucleosome positioning, exchanges histone variants, and assembles and disassembles nucleosomes at certain locations. Moreover, the Snf2 family, in conjunction with other co-factors, regulates gene expression in Saccharomyces cerevisiae. Here we first review recent findings on the Snf2 family remodeling complexes and then use some examples to illustrate the cooperation between different members of Snf2 family, and the cooperation between Snf2 family and other co-factors in gene regulation especially during transcription initiation.

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Acknowledgements

The authors wish to thank laboratory members for discussion and Michelle Hanna for proofreading. This work was supported by the Natural Sciences and Engineering Research Council of Canada Discovery Grant RGPIN-2014-04580 to WX.

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  1. Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, SK, S7N 5E5, Canada

    Aiyang Lin, Ying Du & Wei Xiao

  2. College of Life Sciences, Capital Normal University, Beijing, 100048, China

    Aiyang Lin & Wei Xiao

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  1. Aiyang Lin
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Correspondence to Wei Xiao.

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Lin, A., Du, Y. & Xiao, W. Yeast chromatin remodeling complexes and their roles in transcription. Curr Genet 66, 657–670 (2020). https://doi.org/10.1007/s00294-020-01072-0

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