In this study, the blood pressure-lowering effects of Trichiurus lepturus myosin hydrolysate (TMH) and its possible mechanism were investigated in spontaneously hypertensive rats (SHRs). After gavage administration of TMH for 4 h, systolic blood pressure (SBP) was significantly decreased in SHRs. Furthermore, the SBP of SHRs remained low at 1 month after daily TMH treatment at 400 mg kg-1. Meanwhile, plasma levels of angiotensin II, bradykinin and nitric oxide in SHRs were ameliorated by TMH. Western blotting also suggested that TMH down-regulated the expression of ICAM-1 and VCAM-1, indicating a strong anti-inflammatory effect. Additionally, nitrotyrosine and collagen I were down-regulated, revealing a significant anti-oxidant effect of TMH. No obvious side effects or toxicity were observed in normal Wistar rats given TMH. Various pathogenic factors related to hypertension were improved by TMH, which may explain the underlying mechanism by which TMH synergistically reduces blood pressure.

中文翻译：

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Trichiurus lepturus肌球蛋白水解产物对自发性高血压大鼠的降压作用。

在这项研究中，研究了自发性高血压大鼠（SHRs）的Trichiurus lepturus肌球蛋白水解产物（TMH）的降压作用及其可能的机制。管饲TMH 4小时后，SHRs的收缩压（SBP）明显降低。此外，每日TMH治疗400 mg kg-1后1个月，SHR的SBP仍然很低。同时，TMH改善了SHRs中的血管紧张素II，缓激肽和一氧化氮的水平。Western blotting还提示TMH下调了ICAM-1和VCAM-1的表达，表明其具有很强的抗炎作用。此外，硝基酪氨酸和胶原蛋白I被下调，显示出TMH的显着抗氧化作用。在给予TMH的正常Wistar大鼠中未观察到明显的副作用或毒性。