Issue 4, 2020
From the journal:

Food & Function

Antihypertensive effects of Trichiurus lepturus myosin hydrolysate in spontaneously hypertensive rats

Weiqing Fu,ab   Peixin Wang,ab   Hongqiang Wu,b   Zhigang Zhang,c   Hongliang Zeng,cb   Yi Zhang,abd   Baodong Zheng*ab  and  Jiamiao Hu ORCID logo *be  

* Corresponding authors

a Engineering Research Centre of Fujian-Taiwan Special Marine Food Processing and Nutrition, Ministry of Education, Fuzhou, Fujian, China

b College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China
E-mail: zbdfst@163.com, jiamiao.hu@fafu.edu.cn

c State Key Laboratory of Food Safety Technology for Meat Products, Xiamen, Fujian, China

d China-Ireland International Cooperation Centre for Food Material Science and Structure Design, Fujian Agriculture and Forestry University, Fuzhou, China

e Key Laboratory of Marine Biotechnology of Fujian Province, Institute of Oceanology, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China

Abstract

In this study, the blood pressure-lowering effects of Trichiurus lepturus myosin hydrolysate (TMH) and its possible mechanism were investigated in spontaneously hypertensive rats (SHRs). After gavage administration of TMH for 4 h, systolic blood pressure (SBP) was significantly decreased in SHRs. Furthermore, the SBP of SHRs remained low at 1 month after daily TMH treatment at 400 mg kg−1. Meanwhile, plasma levels of angiotensin II, bradykinin and nitric oxide in SHRs were ameliorated by TMH. Western blotting also suggested that TMH down-regulated the expression of ICAM-1 and VCAM-1, indicating a strong anti-inflammatory effect. Additionally, nitrotyrosine and collagen I were down-regulated, revealing a significant anti-oxidant effect of TMH. No obvious side effects or toxicity were observed in normal Wistar rats given TMH. Various pathogenic factors related to hypertension were improved by TMH, which may explain the underlying mechanism by which TMH synergistically reduces blood pressure.

Graphical abstract: Antihypertensive effects of Trichiurus lepturus myosin hydrolysate in spontaneously hypertensive rats

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Article information

DOI
https://doi.org/10.1039/C9FO02687H
Article type
Paper
Submitted
14 Nov 2019
Accepted
07 Apr 2020
First published
08 Apr 2020

Food Funct., 2020,11, 3645-3656

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Antihypertensive effects of Trichiurus lepturus myosin hydrolysate in spontaneously hypertensive rats

W. Fu, P. Wang, H. Wu, Z. Zhang, H. Zeng, Y. Zhang, B. Zheng and J. Hu, Food Funct., 2020, 11, 3645 DOI: 10.1039/C9FO02687H

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