Abstract

Systemic low-frequency oscillations (sLFOs) are non-neuronal oscillations at 0.01–0.15 Hz. These sLFOs travel through the entire body and the brain with symmetrical (across the midline of the body) and highly predictable delays, where they can be observed with functional near-infrared spectroscopy (fNIRS) and blood oxygen level-dependent functional magnetic resonance imaging. Their characteristics may serve as useful biomarkers for detecting and monitoring circulatory dysfunction. Pure sLFOs can be collected in the periphery (e.g., fingers, toes, earlobes). Here we present a 7-channel NIRS oximeter [MNO] for sLFOs detection and analysis in the periphery, which we named concurrent continuous wave fNIRS system (CON-CW fNIRS). Our CON-CW fNIRS is small (10 × 10 × 20 cm³), highly portable, has low-power consumption and is highly cost-effective (below $300). We show that our device is highly reliable and can reproduce values acquired with a commercial fNIRS device with direct comparison (r_max = 0.908 ∆[HbO] and r_max = 0.841 ∆[Hb]) and when compared to previously published data.

中文翻译：

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用于监视系统低频振荡的低成本多通道NIRS血氧仪

摘要

系统性低频振荡（sLFO）是0.01-0.15 Hz的非神经振荡。这些sLFO在整个身体和大脑中对称传播（穿过身体中线），并具有高度可预测的延迟，可以通过功能性近红外光谱（fNIRS）和依赖于血氧水平的功能性磁共振成像对其进行观察。它们的特征可以用作检测和监测循环功能障碍的有用生物标志物。可以在外周（例如，手指，脚趾，耳垂）中收集纯净的sLFO。在这里，我们提出了一种用于外围检测和分析sLFO的7通道NIRS血氧仪[MNO]，我们将其称为并发连续波fNIRS系统（CON-CW fNIRS）。我们的CON-CW fNIRS很小（10×10×20 cm ³），高度便携，功耗低，成本效益高（低于300美元）。我们证明了我们的设备具有高度的可靠性，并且可以通过直接比较（r _max  = 0.908 ∆ [HbO]和r _max  = 0.841 ∆ [Hb]）并将其与以前发布的数据进行比较，再现使用商用fNIRS设备获得的值。