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A low-cost multichannel NIRS oximeter for monitoring systemic low-frequency oscillations

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Abstract

Systemic low-frequency oscillations (sLFOs) are non-neuronal oscillations at 0.01–0.15 Hz. These sLFOs travel through the entire body and the brain with symmetrical (across the midline of the body) and highly predictable delays, where they can be observed with functional near-infrared spectroscopy (fNIRS) and blood oxygen level-dependent functional magnetic resonance imaging. Their characteristics may serve as useful biomarkers for detecting and monitoring circulatory dysfunction. Pure sLFOs can be collected in the periphery (e.g., fingers, toes, earlobes). Here we present a 7-channel NIRS oximeter [MNO] for sLFOs detection and analysis in the periphery, which we named concurrent continuous wave fNIRS system (CON-CW fNIRS). Our CON-CW fNIRS is small (10 × 10 × 20 cm3), highly portable, has low-power consumption and is highly cost-effective (below $300). We show that our device is highly reliable and can reproduce values acquired with a commercial fNIRS device with direct comparison (rmax = 0.908 ∆[HbO] and rmax = 0.841 ∆[Hb]) and when compared to previously published data.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (61827811), the Hebei Provincial Education Department’s support plan (SLRC2019042) and by the National Institutes of Health, Grants K25 DA031769, R01 NS097512.

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Authors and Affiliations

  1. School of Information Science and Engineering, Yanshan University, Qinhuangdao, 066004, Hebei, China

    Yingwei Li, Yunfei Ma & Shaoqing Ma

  2. McLean Imaging Center, McLean Hospital, Belmont, MA, 02478, USA

    Yingwei Li, Lia Maria Hocke & Blaise deB Frederick

  3. Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47906, USA

    Yunjie Tong

  4. Department of Psychiatry, Harvard Medical School, Boston, MA, 02115, USA

    Lia Maria Hocke & Blaise deB Frederick

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  1. Yingwei Li
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  2. Yunfei Ma
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  3. Shaoqing Ma
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  4. Lia Maria Hocke
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  5. Yunjie Tong
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  6. Blaise deB Frederick
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Correspondence to Yingwei Li or Blaise deB Frederick.

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Li, Y., Ma, Y., Ma, S. et al. A low-cost multichannel NIRS oximeter for monitoring systemic low-frequency oscillations. Neural Comput & Applic 32, 15629–15641 (2020). https://doi.org/10.1007/s00521-020-04897-5

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  • DOI: https://doi.org/10.1007/s00521-020-04897-5

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