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New complexes of pectic polysaccharides with nonsteroidal anti-inflammatory drugs
Russian Chemical Bulletin ( IF 1.7 ) Pub Date : 2020-03-01 , DOI: 10.1007/s11172-020-2801-z
Y. V. Chekunkov , S. T. Minzanova , A. V. Khabibullina , D. M. Arkhipova , L. G. Mironova , A. V. Nemtarev , A. R. Khamatgalimov , A. T. Gubaidullin , V. A. Milyukov

The formation of stable complexes of citrus pectin with nonsteroidal anti-inflammatory drugs, ibuprofen and acetylsalicylic acid (aspirin), was confirmed by IR and NMR spectro scopy. The stoichiometry of complexes with the maximum content of drugs (15 wt. %) was established. A comparative study of the thermal decomposition of pectin and the synthesized complexes with ibuprofen and acetylsalicylic acid was performed by TG/DSC.

中文翻译:

果胶多糖与非甾体抗炎药的新型复合物

红外和核磁共振光谱证实了柑橘果胶与非甾体抗炎药布洛芬和乙酰水杨酸(阿司匹林)的稳定复合物的形成。确定了具有最大药物含量 (15 wt. %) 的复合物的化学计量。通过 TG/DSC 对果胶和合成的布洛芬和乙酰水杨酸复合物的热分解进行了比较研究。
更新日期:2020-03-01
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