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New complexes of pectic polysaccharides with nonsteroidal anti-inflammatory drugs

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Abstract

The formation of stable complexes of citrus pectin with nonsteroidal anti-inflammatory drugs, ibuprofen and acetylsalicylic acid (aspirin), was confirmed by IR and NMR spectro scopy. The stoichiometry of complexes with the maximum content of drugs (15 wt. %) was established. A comparative study of the thermal decomposition of pectin and the synthesized complexes with ibuprofen and acetylsalicylic acid was performed by TG/DSC.

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Authors and Affiliations

  1. A. E. Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences,”, 8 ul. Akad. Arbuzova, 420088, Kazan, Russian Federation

    Y. V. Chekunkov, S. T. Minzanova, A. V. Khabibullina, D. M. Arkhipova, L. G. Mironova, A. V. Nemtarev, A. R. Khamatgalimov, A. T. Gubaidullin & V. A. Milyukov

Authors
  1. Y. V. Chekunkov
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  2. S. T. Minzanova
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  3. A. V. Khabibullina
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  4. D. M. Arkhipova
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  5. L. G. Mironova
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  6. A. V. Nemtarev
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  7. A. R. Khamatgalimov
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  8. A. T. Gubaidullin
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  9. V. A. Milyukov
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Corresponding author

Correspondence to Y. V. Chekunkov.

Additional information

The authors gratefully acknowledge Assigned Spectral-Analytical Center for Study of Struc ture, Composition and Properties of Substances and Materials of the Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences” for providing necessary facilities to carry out this work.

Based on the materials of the International Markovnikov Congress on Organic Chemistry (June 21–28, 2019, Moscow—Kazan, Russia).

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 0572—0580, March, 2020.

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Chekunkov, Y.V., Minzanova, S.T., Khabibullina, A.V. et al. New complexes of pectic polysaccharides with nonsteroidal anti-inflammatory drugs. Russ Chem Bull 69, 572–580 (2020). https://doi.org/10.1007/s11172-020-2801-z

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  • DOI: https://doi.org/10.1007/s11172-020-2801-z

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