Propolis is known to have multiple biological and pharmacological properties including the regulation of energy homeostasis. Although phenolic compounds are considered to be the major active components in propolis, there is little information available about their mechanisms underlying the regulation of energy homeostasis. In this study, the effects of five phenolic compounds in propolis, chrysin, pinocembrin, galangin, pinobanksin, and caffeic acid phenethyl ester (CAPE) were evaluated on the activation of free fatty acid receptor 4 (FFA4), which are involved in the control of energy homeostasis by enhancing insulin signaling, increasing glucose uptake, and regulating adipogenesis. The results showed that three phenolic compounds exhibited the activation of FFA4, which were ranked in the order of pinocembrin, CAPE and pinobanksin in FFA4-expressing cells. These results suggest that some phenolic compounds in propolis, particularly pinocembrin, may affect the control of energy homeostasis via the activation of FFA4.

中文翻译：

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蜂胶酚类化合物对游离脂肪酸受体 4 激活的影响。


众所周知，蜂胶具有多种生物学和药理学特性，包括调节能量稳态。尽管酚类化合物被认为是蜂胶中的主要活性成分，但关于其调节能量稳态的机制的信息很少。在本研究中，评估了蜂胶、白杨素、松香素、高良姜素、松香素和咖啡酸苯乙酯 (CAPE) 中五种酚类化合物对游离脂肪酸受体 4 (FFA4) 激活的影响，这些化合物参与控制通过增强胰岛素信号传导、增加葡萄糖摄取和调节脂肪生成来维持能量稳态。结果表明，3种酚类化合物对FFA4具有激活作用，在表达FFA4的细胞中，其排列顺序为：pinocembrin、CAPE、pinobanksin。这些结果表明，蜂胶中的一些酚类化合物，特别是松香素，可能通过激活 FFA4 来影响能量稳态的控制。