Cervical cancer is the fourth most common type of cancer incidence in the world female population, and it has become a public health problem worldwide. Several factors are involved in this type of cancer, including intrinsic factors related to the inflammatory process, such as extracellular nucleotides and adenosine—components of the purinergic system. The present review focuses on the role of the purinergic system in cervical cancer, especially regarding the interaction of extracellular nucleotides with their respective receptors expressed in the tumor microenvironment of cervical cancer and their role in the host immune response. The high concentrations of extracellular nucleotides in the tumor microenvironment of cervical cancer interfere in the regulation, proliferation, differentiation, and apoptosis of cancer cells of the uterine cervix through different P1 and P2 receptor subtypes. Such diverse cellular processes that are mediated by adenosine triphosphate and adenosine across the tumor microenvironment and that also have effects on host immune defense will be reviewed here in detail.

中文翻译：

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宫颈癌中的嘌呤能信号传导和肿瘤微环境。

宫颈癌是世界女性人群中第四常见的癌症类型，已成为世界范围内的公共卫生问题。此类癌症涉及多种因素，包括与炎症过程相关的内在因素，例如细胞外核苷酸和腺苷（嘌呤能系统的组成部分）。本综述重点关注嘌呤能系统在宫颈癌中的作用，特别是细胞外核苷酸与其在宫颈癌肿瘤微环境中表达的各自受体的相互作用以及它们在宿主免疫反应中的作用。宫颈癌肿瘤微环境中高浓度的细胞外核苷酸通过不同的P1和P2受体亚型干扰宫颈癌细胞的调控、增殖、分化和凋亡。本文将详细回顾肿瘤微环境中三磷酸腺苷和腺苷介导的多种细胞过程，这些过程也对宿主免疫防御产生影响。