Abstract

The use of opioids for the relief of pain and headache disorders has been studied for years. Nowadays, particularly because of its ability to produce analgesia in various pain models, delta opioid receptor (DOPr) emerges as a promising target for the development of new pain therapies. Indeed, their potential to avoid the unwanted effects commonly observed with clinically used opioids acting at the mu opioid receptor (MOPr) suggests that DOPr agonists could be a therapeutic option. In this review, we discuss the use of opioids in the management of pain in addition to describing the evidence of the analgesic potency of DOPr agonists in animal models.

中文翻译：

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阿片类阿片受体激动剂缓解疼痛：实验模型的证据。

摘要

使用阿片类药物缓解疼痛和头痛疾病已有多年研究。如今，特别是由于其能够在各种疼痛模型中产生镇痛作用，δ阿片受体（DOPr）成为开发新的疼痛疗法的有希望的目标。确实，它们有可能避免临床上普遍使用的作用于阿片类阿片受体（MOPr）的阿片类药物带来的不良影响，这表明DOPr激动剂可能是一种治疗选择。在这篇综述中，我们除了描述动物模型中DOPr激动剂的镇痛作用的证据外，还讨论了阿片类药物在疼痛管理中的用途。