Abstract
The use of opioids for the relief of pain and headache disorders has been studied for years. Nowadays, particularly because of its ability to produce analgesia in various pain models, delta opioid receptor (DOPr) emerges as a promising target for the development of new pain therapies. Indeed, their potential to avoid the unwanted effects commonly observed with clinically used opioids acting at the mu opioid receptor (MOPr) suggests that DOPr agonists could be a therapeutic option. In this review, we discuss the use of opioids in the management of pain in addition to describing the evidence of the analgesic potency of DOPr agonists in animal models.
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Acknowledgements
This work was supported by Canadian Institutes of Health Research (CIHR) grants to LG (MOP-136871 and PJT-162103) and a pilot project grant from the Fonds de la Recherche du Québec-Santé (FRQ-S)-funded Quebec Pain Reseach Network (QPRN) (Grant No. 30851). LG is the recipient of a Chercheur-boursier Senior salary support from the FRQ-S.
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Berthiaume, S., Abdallah, K., Blais, V. et al. Alleviating pain with delta opioid receptor agonists: evidence from experimental models. J Neural Transm 127, 661–672 (2020). https://doi.org/10.1007/s00702-020-02172-4
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DOI: https://doi.org/10.1007/s00702-020-02172-4