Purpose

IL-23 is a central proinflammatory cytokine with a wide range of influence over immune response. It is implicated in several autoimmune diseases due to the infinite inflammatory loops it can create through the positive feedbacks of both IL-17 and IL-22 arms. This made IL-23 a key target of autoimmune disorders therapy, which indeed was proven to inhibit inflammation and ameliorate diseases. Current autoimmune treatments targeting IL-23 are either by preventing IL-23 ligation to its receptor (IL-23R) via antibodies or inhibiting IL-23 signaling by signaling downstream mediators’ inhibitors, with each approach having its own pros and cons.

Methods

Literature review was done to further understand the biology of IL-23 and current therapies.

Results

In this review, we discuss the biological features of IL-23 and its role in the pathogenesis of autoimmune diseases including psoriasis, rheumatoid arthritis and inflammatory bowel diseases. Advantages, limitations and side effects of each concept will be reviewed, suggesting several advanced IL-23-based bio-techniques to generate new and possible future therapies to overcome current treatments problems.

中文翻译：

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白介素23和自身免疫性疾病：当前和将来可能的治疗方法

目的

IL-23是一种中枢性促炎细胞因子，对免疫应答具有广泛的影响。由于它可以通过IL-17和IL-22臂的积极反馈产生无限的炎症循环，因此与多种自身免疫性疾病有关。这使IL-23成为自身免疫性疾病治疗的主要靶标，确实证明了它可以抑制炎症并改善疾病。当前针对IL-23的自身免疫治疗是通过阻止IL-23通过抗体与其受体（IL-23R）的连接或通过向下游介质抑制剂发出信号来抑制IL-23信号传导，每种方法各有利弊。

方法

进行了文献综述以进一步了解IL-23的生物学和当前疗法。

结果

在这篇综述中，我们讨论了IL-23的生物学特征及其在自身免疫性疾病（包括牛皮癣，类风湿性关节炎和炎症性肠病）发病机理中的作用。将回顾每个概念的优点，局限性和副作用，并提出几种基于IL-23的先进生物技术，以产生新的和可能的未来疗法来克服当前的治疗问题。