Background

Melanoma is a malignancy that stems from melanocytes and is defined as the most dangerous skin malignancy in terms of metastasis and mortality rates. CXC motif chemokine 10 (CXCL10), also known as interferon gamma-induced protein-10 (IP-10), is a small cytokine-like protein secreted by a wide variety of cell types. CXCL10 is a ligand of the CXC chemokine receptor-3 (CXCR3) and is predominantly expressed by T helper cells (Th cells), cytotoxic T lymphocytes (CTLs), dendritic cells, macrophages, natural killer cells (NKs), as well as some epithelial and cancer cells. Similar to other chemokines, CXCL10 plays a role in immunomodulation, inflammation, hematopoiesis, chemotaxis and leukocyte trafficking.

Conclusions

Recent studies indicate that the CXCL10/CXCR3 axis may act as a double-edged sword in terms of pro- and anti-cancer activities in a variety of tissues and cells, especially in melanoma cells and their microenvironments. Most of these activities arise from the CXCR3 splice variants CXCR3-A, CXCR3-B and CXCR3-Alt. In this review, we discuss the pro- and anti-cancer properties of CXCL10 in various types of tissues and cells, particularly melanoma cells, including its potential as a therapeutic target.

中文翻译：

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CXCL-10：黑色素瘤治疗的新候选人？

背景

黑色素瘤是一种源自黑素细胞的恶性肿瘤，就转移和死亡率而言，被定义为最危险的皮肤恶性肿瘤。CXC基序趋化因子10（CXCL10），也称为干扰素γ诱导蛋白10（IP-10），是一种由多种细胞类型分泌的细胞因子样小蛋白。CXCL10是CXC趋化因子受体3（CXCR3）的配体，主要由T辅助细胞（Th细胞），细胞毒性T淋巴细胞（CTL），树突状细胞，巨噬细胞，天然杀伤细胞（NKs）以及一些上皮和癌细胞。与其他趋化因子相似，CXCL10在免疫调节，炎症，造血，趋化性和白细胞运输中发挥作用。

结论

最近的研究表明，就各种组织和细胞，特别是黑素瘤细胞及其微环境中的抗癌和抗癌活性而言，CXCL10 / CXCR3轴可充当一把双刃剑。这些活动大部分来自CXCR3剪接变体CXCR3-A，CXCR3-B和CXCR3-Alt。在这篇综述中，我们讨论了CXCL10在各种类型的组织和细胞（特别是黑色素瘤细胞）中的抗癌和抗癌特性，包括其作为治疗靶标的潜力。