Purpose

To determine the response of pulmonary function (PF) to the influence of environmental factors in patients with different levels of asthma control.

Materials and methods

Patients with controlled (136 people) and uncontrolled (96 people) asthma living in the conditions of monsoon climate and technogenic pollution in Vladivostok were examined. Discriminant analysis that provides the basis for dividing initial data into classes, as according to standards and expert estimates, was used to calculate ranges of PF response in asthma patients. The selection of discriminant functions with the highest values of constant and coefficient made it possible to identify the optimal quantitative ranges.

Results

Analysis of the discriminant value of Wilks’ lambda (α) has shown that the intensity of PF response to climatic and technogenic factors varies depending on level of disease control (controlled asthma – α = 0.67–0.79, uncontrolled asthma – α =0.05–0.44). The criteria and ranges of PF response also differ depending on level of disease control. In controlled asthma, PF response reflects an adaptive-compensatory dependence. The reaction to the environmental factors is rather weak; therefore, it could be detected by only more sensitive examination method (body plethysmography). In uncontrolled asthma, the response to the influence of environment quality is active and could be clearly identified by spirography.

Conclusions

The climatic and technogenic environment of Vladivostok causes strong pathogenic impact on patients with uncontrolled asthma. The effects of dust fraction 0–1 μm, deeply penetrating into respiratory organs, and day-to-day variability of wind speed, which induces weather sensitivity, are particularly adverse.

中文翻译：

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居住在符拉迪沃斯托克的哮喘患者肺功能反应范围及天气和工业影响的影响标准。

目的

确定不同哮喘控制水平患者肺功能（PF）对环境因素影响的反应。

材料和方法

对生活在符拉迪沃斯托克季风气候和技术污染条件下的哮喘控制患者（136 人）和非控制哮喘患者（96 人）进行了检查。根据标准和专家估计，判别分析为将初始数据分类提供了基础，用于计算哮喘患者的 PF 反应范围。选择具有最高常数和系数值的判别函数使得确定最佳定量范围成为可能。

结果

对 Wilks λ (α) 判别值的分析表明，PF 对气候和技术因素的反应强度取决于疾病控制水平（控制哮喘 - α = 0.67-0.79，未控制哮喘 - α =0.05-0.44 ）。PF 反应的标准和范围也因疾病控制水平而异。在控制性哮喘中，PF 反应反映了一种适应性补偿依赖性。对环境因素的反应比较弱；因此，只能通过更灵敏的检查方法（身体体积描记法）来检测。在不受控制的哮喘中，对环境质量影响的反应是活跃的，可以通过肺活量图清楚地识别出来。

结论

符拉迪沃斯托克的气候和技术环境对未控制的哮喘患者造成强烈的致病影响。0-1 μm 的尘埃，深入呼吸器官，风速的日常变化，导致天气敏感，这些影响尤其不利。