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The response ranges of pulmonary function and the impact criteria of weather and industrial influence on patients with asthma living in Vladivostok

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Abstract

Purpose

To determine the response of pulmonary function (PF) to the influence of environmental factors in patients with different levels of asthma control.

Materials and methods

Patients with controlled (136 people) and uncontrolled (96 people) asthma living in the conditions of monsoon climate and technogenic pollution in Vladivostok were examined. Discriminant analysis that provides the basis for dividing initial data into classes, as according to standards and expert estimates, was used to calculate ranges of PF response in asthma patients. The selection of discriminant functions with the highest values of constant and coefficient made it possible to identify the optimal quantitative ranges.

Results

Analysis of the discriminant value of Wilks’ lambda (α) has shown that the intensity of PF response to climatic and technogenic factors varies depending on level of disease control (controlled asthma – α = 0.67–0.79, uncontrolled asthma – α =0.05–0.44). The criteria and ranges of PF response also differ depending on level of disease control. In controlled asthma, PF response reflects an adaptive-compensatory dependence. The reaction to the environmental factors is rather weak; therefore, it could be detected by only more sensitive examination method (body plethysmography). In uncontrolled asthma, the response to the influence of environment quality is active and could be clearly identified by spirography.

Conclusions

The climatic and technogenic environment of Vladivostok causes strong pathogenic impact on patients with uncontrolled asthma. The effects of dust fraction 0–1 μm, deeply penetrating into respiratory organs, and day-to-day variability of wind speed, which induces weather sensitivity, are particularly adverse.

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Authors and Affiliations

  1. Vladivostok Branch of Federal State Budgetary Science Institution, Far Eastern Scientific Center of Physiology and Pathology of Respiration, Institute of Medical Climatology and Rehabilitative Treatment, Vladivostok, Russian Federation

    Lyudmila V. Veremchuk, Elena E. Mineeva, Tatyana I. Vitkina, Tatyana A. Gvozdenko & Kirill S. Golokhvast

  2. Institute for Complex Analysis of Regional Problems Far Eastern Branch of Russian Academy of Sciences, Birobidzhan, Russian Federation

    Elena A. Grigorieva

  3. Far Eastern Federal University, Vladivostok, Russian Federation

    Kirill S. Golokhvast

Authors
  1. Lyudmila V. Veremchuk
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  2. Elena E. Mineeva
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  3. Tatyana I. Vitkina
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  4. Elena A. Grigorieva
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  5. Tatyana A. Gvozdenko
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  6. Kirill S. Golokhvast
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Corresponding author

Correspondence to Tatyana I. Vitkina.

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Informed consent was obtained from all individual participants included in the study. All procedures performed in studies involving human participants complied with the ethical standards of Ethics Committee of the Vladivostok Branch of Federal State Budgetary Science Institution «Far Eastern Scientific Center of Physiology and Pathology of Respiration» – Institute of Medical Climatology and Rehabilitative Treatment (identification code of the protocol of the Ethics Committee: 10/12–11, approval date: December 07, 2011), and with the Declaration of Helsinki.

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Veremchuk, L.V., Mineeva, E.E., Vitkina, T.I. et al. The response ranges of pulmonary function and the impact criteria of weather and industrial influence on patients with asthma living in Vladivostok. J Environ Health Sci Engineer 18, 235–242 (2020). https://doi.org/10.1007/s40201-020-00458-z

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